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Hatsopoulos, Nicholas G.

One or more keywords matched the following properties of Hatsopoulos, Nicholas G.

Property	Value
overview	Our research focuses on the cortical basis of motor control and learning. We are investigating what features of motor behavior are encoded and how this information is represented in the collective activity of large neuronal ensembles in the motor, premotor, and somatosensory cortices. We are also interested in what way these representations change as motor learning occurs. Our approach has been to simultaneously record neural activity from large groups of neurons using multi-electrode arrays while performing detailed kinematic, kinetic, and muscle measurements of goal-directed, motor behaviors, and to develop mathematical models that relate neural activity with behavior. These mathematical models provide insights as to what aspects of motor behavior are being encoded in cortical neurons, but also can be used to decipher or “decode” neural activity in order to predict movement which has practical implications for brain-machine interface development. Ultimately, this research may lead to neural prosthetic technologies that will allow people with spinal cord injury, ALS, or amputation to use brain signals to voluntarily control a device so as to interact with the world.

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Value

overview

Our research focuses on the cortical basis of motor control and learning. We are investigating what features of motor behavior are encoded and how this information is represented in the collective activity of large neuronal ensembles in the motor, premotor, and somatosensory cortices. We are also interested in what way these representations change as motor learning occurs. Our approach has been to simultaneously record neural activity from large groups of neurons using multi-electrode arrays while performing detailed kinematic, kinetic, and muscle measurements of goal-directed, motor behaviors, and to develop mathematical models that relate neural activity with behavior. These mathematical models provide insights as to what aspects of motor behavior are being encoded in cortical neurons, but also can be used to decipher or “decode” neural activity in order to predict movement which has practical implications for brain-machine interface development. Ultimately, this research may lead to neural prosthetic technologies that will allow people with spinal cord injury, ALS, or amputation to use brain signals to voluntarily control a device so as to interact with the world.

One or more keywords matched the following items that are connected to Hatsopoulos, Nicholas G.

Item Type	Name
Concept	Neural Inhibition
Concept	Neural Pathways
Concept	Neural Prostheses
Academic Article	Coupling the neural and physical dynamics in rhythmic movements.
Academic Article	Bayesian inference of functional connectivity and network structure from spikes.
Academic Article	Exploiting multiple sensory modalities in brain-machine interfaces.
Academic Article	Kinetic trajectory decoding using motor cortical ensembles.
Academic Article	The science of neural interface systems.
Academic Article	Fast and slow oscillations in human primary motor cortex predict oncoming behaviorally relevant cues.
Academic Article	Estimating the directed information to infer causal relationships in ensemble neural spike train recordings.
Academic Article	Coordinate system representations of movement direction in the premotor cortex.
Academic Article	Statistical assessment of the stability of neural movement representations.
Academic Article	The problem of parametric neural coding in the motor system.
Academic Article	Real-time decoding of nonstationary neural activity in motor cortex.
Academic Article	Neural decoding of hand motion using a linear state-space model with hidden states.
Academic Article	Neural discharge and local field potential oscillations in primate motor cortex during voluntary movements.
Academic Article	Instant neural control of a movement signal.
Academic Article	Multiplication and stimulus invariance in a looming-sensitive neuron.
Academic Article	Encoding in the motor cortex: was evarts right after all? Focus on "motor cortex neural correlates of output kinematics and kinetics during isometric-force and arm-reaching tasks".
Academic Article	Encoding of movement fragments in the motor cortex.
Academic Article	Behavioral demonstration of a somatosensory neuroprosthesis.
Academic Article	Improving brain-machine interface performance by decoding intended future movements.
Academic Article	Heterogeneous neural coding of corrective movements in motor cortex.
Academic Article	Granger causality analysis of functional connectivity of spiking neurons in orofacial motor cortex during chewing and swallowing.
Academic Article	Tracking single units in chronic, large scale, neural recordings for brain machine interface applications.
Academic Article	Consideration of the functional relationship between cortex and motor periphery improves offline decoding performance.
Academic Article	Motor cortex microcircuits.
Academic Article	Neural coordination during reach-to-grasp.
Academic Article	Comparing offline decoding performance in physiologically defined neuronal classes.
Academic Article	Primary motor and sensory cortical areas communicate via spatiotemporally coordinated networks at multiple frequencies.
Academic Article	Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate.
Academic Article	High-frequency oscillations in human and monkey neocortex during the wake-sleep cycle.
Academic Article	Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex.
Academic Article	Nonmonotonic spatial structure of interneuronal correlations in prefrontal microcircuits.
Academic Article	Dynamics of motor cortical activity during naturalistic feeding behavior.
Academic Article	Decoding hand kinematics from population responses in sensorimotor cortex during grasping.
Academic Article	Neural population dynamics in motor cortex are different for reach and grasp.
Academic Article	Chronic wireless neural population recordings with common marmosets.
Academic Article	Longevity and reliability of chronic unit recordings using the Utah, intracortical multi-electrode arrays.
Academic Article	Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex.

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Neural
Oscillations